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49ers Face Injury Questions for 2026 Season

Published July 29, 2026 · Updated July 29, 2026 · Fox Sports

Despite winning 12 games in 2025 despite significant injuries, the San Francisco 49ers enter 2026 with questions about health and a projected win total of 9.5.

The San Francisco 49ers have maintained excellence since 2019 with five 10-win seasons, but injuries have plagued their recent campaigns. In 2025, despite losing over $95 million in salary cap value to injured players, they still won 12 games in the NFC West, which saw the Seahawks win 14 and the Rams win 12. palladian.co.za

Key players including Brock Purdy (8 games missed), Fred Warner, and Nick Bosa (season-ending injuries) missed significant time, along with George Kittle, Ricky Pearsall, Talanoa Hufanga, and Brandon Aiyuk. For 2026, the 49ers are favored to win Over 9.5 games (-146) rather than Under (+120), and are +305 to win the NFC West, +960 to win the NFC, and +1900 to win the Super Bowl.

49ers Face Injury Questions for 2026 Season

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